abstract：:The receptor for macrophage colony-stimulating factor (M-CSF) is expressed in monocytes/macrophages and their progenitor cells and stimulates both the growth and development of the blood-cell lineage. Although the specific components positively regulating M-CSF receptor signaling have been relatively well defined, it ...

journal_title：International journal of hematology

authors： Suzu S,Motoyoshi K

更新日期：2002-07-01 00:00:00

abstract：:The correlation between infant leukemia and in utero exposure to topoisomerase II (topo-II) inhibitor has been clarified. We examined the in vitro effect of topo-II inhibitor (etoposide) on cleavage of the MLL gene in cord and peripheral blood mononuclear cells (MNCs). Southern blot analysis showed cleavage of the MLL...

journal_title：International journal of hematology

authors： Ishii E,Eguchi M,Eguchi-Ishimae M,Yoshida N,Oda M,Zaitsu M,Fujita I,Miyazaki S,Hamasaki Y,Mizutani S

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:The chronic myeloproliferative diseases (CMPDs) include chronic myelogenous leukemia (CML), primary (essential) thrombocythemia (PT), agnogenic myeloid metaplasia (AMM), and polycythemia vera (PV). Certain hematological malignancies have a different prevalence in our country than in countries with Caucasian ...

journal_title：International journal of hematology

authors： Ruiz-Argüelles GJ,López-Martínez B,Lobato-Mendizábal E,Ruiz-Delgado GJ

更新日期：2002-06-01 00:00:00

abstract：:A series of expression microarray analyses of chronic myeloid leukemia (CML) by means of complementary DNA microarray representing a set of 1024 human genes were initiated to evaluate the role of expression microarray analysis in CML and to identify CML-associated genes. Among the target genes, 388 differentially expr...

journal_title：International journal of hematology

authors： Li H,Jie S,Zou P,Zou G

更新日期：2002-05-01 00:00:00

abstract：:The widespread use of tissue including hematopoietic stem cell products is justification for the development of standards by professional societies and for regulation by governmental agencies. The Food and Drug Administration (FDA) developed a tiered, risk-based regulatory model. At the low end of risk to the tissue r...

journal_title：International journal of hematology

authors： Rowley SD

更新日期：2002-04-01 00:00:00

abstract：:A 38-year-old Japanese man with myelodysplastic syndrome (MDS), whose bone marrow smears demonstrated hypercellularity, was treated with oral cyclosporin A (CsA) therapy. During the course of this therapy, the numbers of peripheral blood and bone marrow blasts increased and the level of serum lactate dehydrogenase inc...

journal_title：International journal of hematology

authors： Itoh M,Yago K,Shimada H,Tohyama K

更新日期：2002-04-01 00:00:00

abstract：:The phenotypic distributions of observed numbers of ABO blood groups in a Kuwaiti sample population of 18,558 subjects are 4962 (26.7%) with A, 4,462 (24.1%) with B, 858 (4.6%) with AB, and 8,276 (44.6%) with 0. The calculated gene frequencies are 0.6678 for ABO*O, 0.1768 for ABO*A, and 0.1554 for ABO*B. Molecular gen...

journal_title：International journal of hematology

authors： Al-Bustan S,El-Zawahri M,Al-Azmi D,Al-Bashir AA

更新日期：2002-02-01 00:00:00

abstract：:A 2-year-old Japanese boy who presented with multiple cervical, axillary, and inguinal lymphadenopathy was diagnosed by immunocytochemical analysis as having myeloid/natural killer (NK) cell precursor acute leukemia. Leukemic blasts in the bone marrow were positive for CD56 (NK marker), CD7 (T-cell marker), CD33 (myel...

journal_title：International journal of hematology

authors： Tezuka K,Nakayama H,Honda K,Suzumiya J,Oshima K,Kitoh T,Ishii E

更新日期：2002-02-01 00:00:00

abstract：:A 76-year-old Japanese woman was hospitalized for ileus symptoms caused by extensive thrombosis of the superior mesenteric vein. Because laboratory test results suggested type III protein S (PS) deficiency, molecular changes in PS were investigated. A single-base transition, CCG to CTG at codon 626 in exon XV, resulti...

journal_title：International journal of hematology

authors： Kato M,Iida S,Sato M,Hayami Y,Hanamura I,Miura K,Ito M,Harada S,Komatsu H,Wakita A,Manabe T,Ueda R

更新日期：2002-01-01 00:00:00

abstract：:We retrospectively analyzed 126 acute myelogenous leukemia (AML) patients aged > or =60 years who had all been referred to the same hematological department between 1989 and 1999. In 76 de novo AML cases, 53 patients (median age, 72 years) were treated with combination chemotherapy (CT) for remission induction. Comple...

journal_title：International journal of hematology

authors： Iwakiri R,Ohta M,Mikoshiba M,Tsutsumi H,Kumakawa T,Mori M

更新日期：2002-01-01 00:00:00

abstract：:A 32-year-old male patient with severe factor VIII (FVIII) deficiency had developed a high-titer FVIII inhibitor at age 13. Recurrent hemarthroses caused bony destruction in both knees, significantly impairing his ability to walk. Knee examination revealed 20 degrees of varus, destruction of the medial joint line, and...

journal_title：International journal of hematology

authors： Carr ME Jr,Loughran TP,Cardea JA,Smith WK,Kuhn JG,Dottore MV

更新日期：2002-01-01 00:00:00

abstract：:Under influence of hematopoietic growth factors, particularly thrombopoietin (TPO), hematopoietic stem cells in the bone marrow go through a process of commitment, proliferation, differentiation, and maturation and become mature megakaryocytes. At this critical point, terminally differentiated megakaryocytes face a ne...

journal_title：International journal of hematology

authors： Li J,Kuter DJ

更新日期：2001-12-01 00:00:00

abstract：:Bleeding is reportedly one of the major causes of death in patients with chronic neutrophilic leukemia (CNL), but thrombocytopenia, abnormal platelet functions, or coagulopathy has been confirmed to be the cause of the bleeding tendency in only a small proportion of the patients. We report the case of a 49-year-old wo...

journal_title：International journal of hematology

authors： Noguchi T,Ikeda K,Yamamoto K,Ashiba A,Yoshida J,Munemasa M,Takenaka K,Shinagawa K,Ishimaru F,Yoshino T,Niiya K,Harada M

更新日期：2001-12-01 00:00:00

abstract：:Chromosomal translocations are one of the hallmarks of human leukemias. These structural abnormalities result in the generation of genetic mutations that play a direct role in the transformation of hematopoietic stem cells. Some of the most common targets of these chromosomal rearrangements are the genes that encode t...

journal_title：International journal of hematology

authors： Lorsbach RB,Downing JR

更新日期：2001-10-01 00:00:00

abstract：:We describe a variant form, French-American-British (FAB) M3v, of acute promyelocytic leukemia (APL; FAB M3) with atypical morphocytochemical features, immature antigens (CD34 and HLA-DR) and marked myelofibrosis (MF). Usual APL cells do not express CD34 or HLA-DR antigens. MF may be more frequently observed in patien...

journal_title：International journal of hematology

authors： Fukuno K,Tsurumi H,Yoshikawa T,Yamada T,Oyama M,Moriwaki H

更新日期：2001-10-01 00:00:00

abstract：:Neutrophils and other phagocytes migrate to the site of infection, ingest pathogens, and destroy them after releasing granule contents and active oxygen. These activities of the cells are closely associated with a rapid reorganization of the cytoskeleton, in which actin polymerizes, cross-links, anchors to the membran...

journal_title：International journal of hematology

authors： Nunoi H,Yamazaki T,Kanegasaki S

更新日期：2001-08-01 00:00:00

abstract：:The clinicopathological and biological significance of Hodgkin's disease and non-Hodgkin's lymphoma, which are infrequently encountered in women of childbearing age, remains to be clarified. We recently reviewed 4 cases of non-Hodgkin's lymphoma of the T/natural killer (T/NK)-cell phenotype, all of which were associat...

journal_title：International journal of hematology

authors： Kato M,Ichimura K,Hayami Y,Iida S,Wakita A,Ueda R,Nakamura S

更新日期：2001-08-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is a pleiotropic regulator of all stages of hematopoieis. Depending on the differentiation stage of the target cell, the local environment, and the concentration of TGF-beta, TGF-beta can be proproliferative or antiproliferative, proapoptotic or antiapoptotic, and/or prodiffe...

journal_title：International journal of hematology

authors： Ruscetti FW,Bartelmez SH

更新日期：2001-07-01 00:00:00

abstract：:We evaluated the engraftment and the cell cycle status of marrow cells at various times after 5-fluorouracil (5-FU) administration. 5-FU (150 mg/kg) was given to donor male BALB/c mice at 1, 2, 6, or 12 days prior to marrow harvest. The donor cells were then assessed in host nonmyeloablated female mice. Bone marrow en...

journal_title：International journal of hematology

authors： D'Hondt L,Carlson J,Benoit B,Reilly J,Grimaldi C,Wuu J,Lambert JF,Dooner MS,Quesenberry PJ

更新日期：2001-07-01 00:00:00

abstract：:Mouse embryos homozygous for a targeted disruption in the Fli-1 gene show hemorrhage into the neural tube and brain on embryonic day (E)11.0 and die shortly thereafter. Livers from the mutant embryos contain drastically reduced numbers of pronormoblasts, basophilic normoblasts, and colony-forming cells. To determine t...

journal_title：International journal of hematology

authors： Kawada H,Ito T,Pharr PN,Spyropoulos DD,Watson DK,Ogawa M

更新日期：2001-06-01 00:00:00

abstract：:This study describes the frequency of monoclonal gammopathy of undetermined significance (MGUS) and the changes in some inflammation-related serum proteins in 157 patients with nonimmune chronic idiopathic neutropenia syndrome (NI-CINS). Of these patients, 42 had pronounced neutropenia with neutrophil counts < 1500/mi...

journal_title：International journal of hematology

authors： Papadaki HA,Eliopoulos DG,Ponticoglou C,Eliopoulos GD

更新日期：2001-04-01 00:00:00

abstract：:In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 40 and 80 microg/g. In addition, intravenous injection of TMPZ (10 microg/g) significantly prolonged the bleeding time by approximately 1....

journal_title：International journal of hematology

authors： Sheu JR,Hsiao G,Lee YM,Yen MH

更新日期：2001-04-01 00:00:00

abstract：:Detection of autoantibodies to erythrocytes is of fundamental importance in the diagnosis of autoimmune hemolytic anemia (AIHA). The routinely used direct antiglobulin test (DAT) has the disadvantage of low sensitivity. In this study, we investigated the optimal test conditions of measurement of red blood cell (RBC)-b...

journal_title：International journal of hematology

authors： Wang Z,Shi J,Zhou Y,Ruan C

更新日期：2001-02-01 00:00:00

abstract：:The antitumor effect of high-dose chemotherapy (HDC) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) is considered superior to that of conventional chemotherapy. However, the long-term benefits of this strategy in Japan remain unclear. Therefore, in this study, 109 cancer patients enroll...

journal_title：International journal of hematology

authors： Kohda K,Sakamaki S,Matsunaga T,Kuga T,Fujimi A,Konuma Y,Kusakabe T,Kogawa K,Akiyama T,Koike K,Hirayama Y,Sasagawa Y,Nojiri S,Hirata Y,Nishisato T,Niitsu GY,Hokkaido Society of Peripheral Blood Stem Cell Transplantation.

更新日期：2001-02-01 00:00:00

abstract：:Gene-marking studies were the first approved clinical protocols introducing exogenous genetic material into human cells. Such studies were never intended to provide direct therapeutic benefit. Instead, they were expected to provide information about normal cell biology and disease pathogenesis that could not be obtain...

journal_title：International journal of hematology

authors： Bollard CM,Heslop HE,Brenner MK

更新日期：2001-01-01 00:00:00

abstract：:Recent studies have indicated that Fas and perforin-based mechanisms seem to induce apoptosis in histiocytic necrotizing lymphadenitis (HNL). In this study, we evaluated the serum levels of soluble Fas ligand (sFasL) in 30 HNL patients using paired sera. Elevations in sFasL levels were detected in 9 patients in the ac...

journal_title：International journal of hematology

authors： Kato K,Ohshima K,Anzai K,Suzumiya J,Kikuchi M

更新日期：2001-01-01 00:00:00

abstract：:Integrins, a family of noncovalently associated alpha beta heterodimeric adhesion receptors, are involved in a variety of pathological and physiological processes. The importance of integrins is evident in the severe pathogenic consequences of their congenital deficiencies: Glanzmann thrombasthenia (GT) and leukocyte ...

journal_title：International journal of hematology

authors： Tomiyama Y

更新日期：2000-12-01 00:00:00

abstract：:We report our experience with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) following a nonmyeloablative conditioning regimen consisting of cytarabine (8 g/m2) and cyclophosphamide (120 mg/kg) in the treatment of 2 patients aged 50 and 55 years with refractory chronic myelomonocytic leukemia and c...

journal_title：International journal of hematology

authors： Fujii N,Maeda Y,Takenaka K,Shinagawa K,Imai T,Kozuka T,Ikeda K,Sunami K,Hiramatsu Y,Ishimaru F,Niiya K,Harada M

更新日期：2000-12-01 00:00:00

abstract：:The majority of adults diagnosed with acute myeloid leukemia (AML) display acquired cytogenetic aberrations at presentation. Numerous recurring chromosomal abnormalities have been and continue to be identified in AML. In many instances, genes altered by these aberrations have been cloned, providing insights into the m...

journal_title：International journal of hematology

authors： Mrózek K,Heinonen K,Bloomfield CD

更新日期：2000-10-01 00:00:00

abstract：:Cellular and extracellular alterations of various fibrogenic cytokines have been described in a number of different chronic myeloid disorders that are associated with myelofibrosis. However, the available information related to both myelodysplastic syndrome with myelofibrosis (MDS-f) and bone marrow histochemical anal...

journal_title：International journal of hematology

authors： Yoon SY,Li CY,Lloyd RV,Tefferi A

更新日期：2000-10-01 00:00:00

abstract：:At present, the only 2 treatments that can prolong survival in patients with myelodysplastic syndrome (MDS) are allogeneic stem cell transplantation and intensive chemotherapy. Alternatives to myeloablative or conventional chemotherapy include: (1) supportive therapy, (2) stimulation of normal residual hematopoietic p...

journal_title：International journal of hematology

authors： Cazzola M

更新日期：2000-08-01 00:00:00

abstract：:We report 2 paroxysmal nocturnal hemoglobinuria (PNH) patients who were initially diagnosed with aplastic anemia and sequentially developed PNH, myelodysplastic syndromes (MDS), and leukemia. Flow cytometry and cytogenetic analysis showed the initial appearance and expansion of PNH clones, gradual replacement of PNH c...

journal_title：International journal of hematology

authors： Ishihara S,Nakakuma H,Kawaguchi T,Nagakura S,Horikawa K,Hidaka M,Asou N,Mitsuya H

更新日期：2000-08-01 00:00:00

abstract：:To determine the pathogenesis of hemophagocytic lymphohistiocytosis (HLH), serum levels of neuron-specific enolase (NSE) and cytokine profiles were investigated. Serum concentrations of NSE and several cytokines were measured by immunoassays, and the association was evaluated in 18 HLH patients. Serum NSE levels incre...

journal_title：International journal of hematology

authors： Honda K,Ohga S,Takada H,Nomura A,Ohshima K,Kinukawa N,Mizuno Y,Hara T

更新日期：2000-07-01 00:00:00

abstract：:The central pathogenic feature of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) is the formation of platelet aggregates, perhaps by damaged endothelial cells. The evidence for endothelial cell damage has been supported by multiple findings, including the harmful effects of TTP/HUS plasma, whi...

journal_title：International journal of hematology

authors： Kakishita E

更新日期：2000-06-01 00:00:00

abstract：:We report a patient with acute monocytic leukemia (AMoL; M5) who received a second bone marrow transplantation (BMT) with graft-versus-leukemia (GVL) effect on relapsed leukemia cutis, which had been refractory to intensive chemotherapy and donor lymphocyte transfusions (DLTs). A 21-year-old woman was diagnosed with A...

journal_title：International journal of hematology

authors： Ashida T,Kawanishi K,Ariyama T,Hamasaki H,Maeda Y,Tsubaki K,Kanamaru A

更新日期：2000-06-01 00:00:00

abstract：:Kinetic resistance is assumed to be one of the main mechanisms of drug resistance in acute myeloid leukemia (AML), but the relationship between cell cycle status at diagnosis and achievement of complete remission (CR) is controversial. Based on the possibility that the cell cycle data after starting induction chemothe...

journal_title：International journal of hematology

authors： Kamikubo KH,Ogata K,An E,Dan K

更新日期：2000-04-01 00:00:00

abstract：:Hematopoiesis is closely linked with angiogenesis, because they interact with each other and have common ancestors: hemangioblasts or hematogenic endothelial cells. The relationship is reasonable, because vascular and hematopoietic systems must develop together in order to establish the body's oxygen-delivery system d...

journal_title：International journal of hematology

authors： Suda T,Takakura N,Oike Y

更新日期：2000-02-01 00:00:00

abstract：:Neurological complications in thrombotic thrombocytopenic purpura (TTP) are associated with poor prognosis and/or permanent damage. We report a young woman in whom the diagnosis of TTP was difficult because cardinal manifestations were absent at presentation. The patient relapsed, showing severe and dramatic neurologi...

journal_title：International journal of hematology

authors： Rabkin Y,Fradin Z,Zeidman A,Schwartz A,Cohen A,Mittelman M

更新日期：2000-02-01 00:00:00

abstract：:Hematopoietic cells can be exposed to a wide spectrum of oxidative stresses. Excessive oxidative stress damages biomolecules such as DNA, proteins, and lipids, leading to cellular dysfunction and cell death. Accumulation of such damage provokes noxious effects on individuals, resulting in diseases such as hematopoieti...

journal_title：International journal of hematology

authors： Masutani H

更新日期：2000-01-01 00:00:00

abstract：:We studied a 29-year-old Japanese male patient with factor XI deficiency; we also studied his parents and one sibling. Factor XI coagulation activity and antigen levels were extremely low (less than 1% of normal level) in both the patient and his brother, and they were half the normal levels in both parents. Sequence ...

journal_title：International journal of hematology

authors： Kawaguchi T,Koga S,Hongo H,Komiyama Y,Li K,Ishihara S,Horikawa K,Hidaka M,Mitsuya H,Nakakuma H

更新日期：2000-01-01 00:00:00